Publications

*: Corresponding author; Underline: trainees of Dr. Hong Chen.

Under review

35. Zhu LF, Nazeri A, Michael B. Altman, Nima Sharifai, Richard J. Perrin, Dinesh Thotala, Dennis E. Hallahan, Chen H*, Ultrasound-targeted microbubble destruction for glioblastoma therapy: a comparison study with radiation therapy, Phys. Med. Biol

34. Zhu LF, Partanen A, Talcott MR, Gach MH, Greco SC, Henke LE, Contreas JA, Zoberi I, Hallahan DE, Chen H, Altman M, Safety and feasibility of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-mediated mild hyperthermia in pelvic targets evaluated using an in vivo porcine model, International Journal of Hyperthermia

33. Shanshan Xu, Dezhuang Ye, Leighton Wan, Yoga Shentu, Yimei Yue, Mingxi Wan, Chen H*, Correlation between brain tissue damage and cavitation doses quantified using passive cavitation imaging, Ultrasound Med. Biol

32. Zhu LF, Nazeri A, Yue YM, Liu WJ, Wang XW, Petti AA, Leuthardt EC, Dunn GP, Chen H*, Optimization of Focused Ultrasound-enabled Brain Tumor Liquid Biopsy (FUS-LBx), Scientific Reports 

2019

31.Yaoheng Yang, Xiaohui Zhang, Dezhuang Ye, Richard Laforest, Jeffrey Williamson, Yongjian Liu, Hong Chen*Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption, Scientific Reports, 2019;9(1):2840 Altmetric Score: 104 (in the 97th percentile of the 146,195 tracked articles of a similar age in all journals).

30. Lifei Zhu, William Straube, Imran Zoberi, Dennis E. Hallahan, Michael B. Altman, Hong Chen*, Ultrasound hyperthermia technology for radiosensitization, Ultrasound in Medicine and Biology 2019;45(5):1025-1043

2018

29. Ye DZ, Zhuang XH, Yue YM, Raliya R, Biswas P, Taylor S, Tai YC, Rubin JB, Liu YJ, Chen H*Focused ultrasound-enhanced intranasal delivery of gold nanoclusters to the pons with minimized systemic exposure, Journal of Controlled Release 2018;286:145-153

28. Kothapalli S, Partanen A, Zhu LF, Altman M, Gach HM, Hallahan D, Chen H*A convenient, reliable, and fast acoustic pressure field measurement method for magnetic resonance-guided focused ultrasound systems with phased array transducers, Journal of Therapeutic Ultrasound  2018, 6:5

27. Ye DZ, Sultan D, Yue YM, Heo GS, Kothapalli S, Luehmann H, Tai YC, Rubin JB, Liu YJ*, Chen H*Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons, Journal of Controlled Release 2018;283:143-150

26. Sultan D, Ye DZ, Heo GS, Zhang XH, Luehmann H, Yue YM, Detering L, Komarov S, Taylor S, Tai YC, Rubin JB, Chen H*, Liu YJ*. Focused Ultrasound Enabled Positron Emission Tomography Imaging of Trans-Blood Brain Barrier Delivery Using 64Cu-Integrated Ultrasmall Gold Nanoclusters, Small  2018:1703115. (*: co-first authors; #: co-corresponding authors)

25. Zhu LF, Cheng G, Ye DZ, Nazeri A, Yue YM, Liu WJ, Wang XW, Dunn GP, Petti AA, Leuthardt EC, Chen H*, Focused Ultrasound-enabled Brain Tumor Liquid Biopsy, Scientific Reports 2018:8 (*: co-first authors) Altmetric Score: 115 (in the 97th percentile of the 254,217 tracked articles of a similar age in all journals)

24. Kothapalli S, Altman M, Zhu LF, Cheng G, Partanen A, Gach HM, Zoberi I, Hallahan D, and Chen H*. Evaluation and selection of anatomic sites for magnetic resonance imaging-guided mild hyperthermia therapy: a healthy volunteer study. International Journal of Hyperthermia. 2018 Jan 4:1-9.

2017

23. Kothapalli S, Partanen A, Zhu LF, Altman M, Gach MH, Hallahan DE, Chen H*. Acoustic field characterization of a clinical magnetic resonance-guided high-intensity focused ultrasound system inside the magnet bore. Med. Phys. 2017;44:4890–4899.

22. Eranki A, Farr N, Partanen A, Sharma KV, Chen H, Rossi CT, Kothapalli SV, Oetgen M, Kim A, Negussie AH, Woods D. Boiling histotripsy lesion characterization on a clinical magnetic resonance imaging-guided high intensity focused ultrasound system. PloS one. 2017 Mar 16;12(3):e0173867.

BEFORE JOINING WUSTL

21. Chen H, Yang GZX, Getachew H, Acosta C, Sierra Sánchez C, Konofagou EE. Focused ultrasound-enhanced intranasal brain delivery of brain-derived neurotrophic factor. Sci Rep 2016;6:28599.

20. Payen T, Palermo C, Sastra S, Chen H, Yang H, Olive K, Konofagou EE. "Elasticity mapping of murine abdominal organs in vivo using harmonic motion imaging (HMI).Physics in Medicine and Biology 2016; 61(15): 5741.

19. Kamimura, H.A., Wang, S., Chen, H., Wang, Q., Aurup, C., Acosta, C., Carneiro, A.A. and Konofagou, E.E.,  Focused ultrasound neuromodulation of cortical and subcortical brain structures using 1.9 MHzMedical Physics, 2016; 43(10): 5730-5735.

18. Zhou YF, Wang Y-N, Farr N, Zia J, Chen H, Ko BM, Khokhlova T, Li T, Hwang JH, Enhancement of small molecule delivery by pulsed high-intensity focused ultrasound: A parameter exploration. Ultrasound in Medicine and Biology. 2016;42(4):956-63

17. Chen H, Hou G, Han Y, Payen T, Palermo CF, Olive KP, Konofagou EE, Harmonic motion imaging for abdominal tumor detection and high-intensity focused ultrasound ablation monitoring: a feasibility study in a transgenic mouse model of pancreatic cancerIEEE transactions on ultrasonics, ferroelectrics, and frequency control. 2015; 62(9): 1662-1673.

16. Li T, Wang Y-N, Khokhlova T, D'Andrea S, Starr F, Chen H, McCune JS, Risler LJ, Mashadi-Hossein A, Hwang JH, Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in the KPC mouse model of pancreatic cancerCancer Research. 2015; canres-0296.

15. Chen H, Chen C, Wu SY, Sun T, Acosta C, Konofagou EE. A new brain drug delivery strategy: Focused ultrasound-enhanced intranasal drug deliveryPLoS ONE. 2014; 9(10): e108880

14. Chen H, Konofagou EE. The size of blood-brain barrier opening induced by focused ultrasound is dictated by the acoustic pressureJournal of cerebral blood flow and metabolism. 2014; 34(7):1197–1204

13. Li T, Chen H, Khokhlova TD, Wang YN, Kreider W, He XM, Hwang JH, Passive cavitation detection during pulsed HIFU exposures of ex vivo tissues and in vivo mouse pancreatic tumorsUltrasound in Medicine and Biology. 2014; 40(7): 1523-1534

12. Chen H, Hwang JH. Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors.  Journal of Therapeutic Ultrasound. 2013;1(1):10

11. Hosseinkhah N, Chen H, Matula TJ, Burns P, Hynynen K. Mechanisms of microbubble-vessel interactions and induced stresses: a numerical model to describe the microbubble/fluid/vessel system. Journal of Acoustical Society of America. 2013; 134(3): 1875-1885

10. Perez C, Chen H, Karzova M, Khokhlova V, Matula TJ. Acoustic field characterization of the Duolith: Measurements and modeling of a clinical shockwave therapy deviceJournal of Acoustical Society of America. 2013; 134(2): 1663-1674

9. Chen H, Brayman AA, Matula TJ. Characteristic microvessel relaxation timescales associated with ultrasound-activated microbubblesApplied Physics Letters. 2012; 101(16): 163704

8. Chen H, Brayman AA, Evan AP, Matula TJ. Preliminary observations on the spatial correlation between short-burst microbubble oscillations and vascular bioeffectsUltrasound in Medicine and Biology. 2012:38: 2151-2162

7. Chen H, Kreider W, Brayman AA, Bailey MR, Matula TJ. Blood vessel deformations on microsecond time scales by ultrasonic cavitationPhysical Review Letters. 2011; 106(3): 034301.

6. Chen H, Brayman AA, Kreider W, Bailey MR, Matula TJ. Observations of translation and jetting of ultrasound-activated microbubbles in mesenteric microvesselsUltrasound in Medicine and Biology. 2011; 37(12): 2139-4218.

5. Chen H, Brayman AA, Bailey MR, Matula TJ. Blood vessel rupture by cavitationUrological Research. 2010; 38(4): 321-326.

4. Chen H, Li XJ, Wan MX, Wang SP. High-speed observation of cavitation bubble clouds near a tissue boundary in high-intensity focused ultrasound fieldsUltrasonics. 2009; 49(3): 289-292.

3. Chen H, Li XJ, Wan MX, Wang SP. High-speed observation of cavitation bubble cloud structures in the focal region of a 1.2 MHz high-intensity focused ultrasound transducer. Ultrasonics Sonochemistry. 2007;14(3): 291-297.

2. Chen H, Li XJ, Wan MX. Spatial-temporal dynamics of cavitation bubble clouds in 1.2 MHz focused ultrasound fieldUltrasononics Sonochemistry. 2006; 13(6): 480-486.

1. Chen H, Li XJ, Wan MX. The inception of cavitation bubble clouds induced by high-intensity focused ultrasoundUltrasonics. 2006; 44: e427-e29.

2018

Yang YH, Ye DZ, Zhang XH, Xu SS, Liu YJ, Chen H. Correlation between passive cavitation imaging and positron emission tomography imaging of the radiolabeled nanocluster delivery location and efficiency by FUS-mediated blood-brain barrier disruption. IEEE International Ultrasonics Symposium, Kobe, Japan, 2018 (Oral presentation)

Zhu LF, Altman M, Yue YM, Nazeri A, Chen H. Ultrasound-mediated microbubble destruction suppressed mouse glioblastoma growth as effectively as radiation therapy. IEEE International Ultrasonics Symposium, Kobe, Japan, 2018 (Oral presentation)

Zhu LF, Cheng G, Ye DZ, Nazeri A, Yue YM, Liu WJ, Wang XW, Dunn GP, Petti AA, Leuthardt EC, Chen H. Focused ultrasound-enabled brain tumor liquid biopsy. IEEE International Ultrasonics Symposium, Kobe, Japan, 2018 (Oral presentation)

Ye DZ, Zhuang XH, Yue YM, Taylor S, Tai YC, Rubin JB, Liu YJ, Chen H. Comparison of focused ultrasound-mediated intranasal brain drug delivery and focused ultrasound-induced blood-brain barrier disruption in the delivery of gold nanoclusters to the brainstem. IEEE International Ultrasonics Symposium, Kobe, Japan, 2018 (Oral presentation)

Yang YH, Xu SS, Wan L, Ye DZ, Yue YM, Chen H. Spatiotemporal dynamics of cavitation fields induced by focused ultrasound activation of microbubbles through an ex vivo human skull. The 18th International Symposium for Therapeutic Ultrasound, Nashville, Tennessee, 2018 (Oral presentation)

Zhu LF, Yang YH, Chen H, Altman M. A method for quality assurance in magnetic resonance imaging-guided high intensity focused ultrasound (MRgHIFU) mild hyperthermia. 35th Annual Society for Thermal Medicine Meeting, Tucson, Arizona, 2018 (Oral presentation)

Ye DZ, Zhuang XH, Yue YM, Raliya R, Biswas P, Taylor S, Tai YC, Rubin JB, Liu YJ, Chen H. Focused ultrasound-mediated intranasal delivery for noninvasive and spatially-targeted brain drug delivery with minimal systemic exposure. The 18th International Symposium for Therapeutic Ultrasound, Nashville, Tennessee, 2018 (Oral presentation)

Zhu LF, Altman M, Yue YM, Partanen A, Thotala D, Hallahan DE, Chen H. Focused ultrasound in combination with microbubbles for enhancing radiation therapy of glioblastoma in an orthotopic mouse model. The 18th International Symposium for Therapeutic Ultrasound, Nashville, Tennessee, 2018 (Poster)

Ye DZ, Zhuang XH, Yue YM, Taylor S, Tai YC, Rubin JB, Liu YJ, Chen H. Microbubble perivascular pump effect for enhancing the local delivery efficiency of intranasally-administered agents. 23rd European Symposium on ultrasound contrast imaging, Rotterdam, The Netherlands, 2018 (Invited talk)

2017

Kothapalli S., Altman M., Wang ZR, Partanen A., Gach HM, Straube W., Hallahan D., and Chen H.. A quick and reliable acoustic calibration method for a clinical MR-guided high-intensity focused ultrasound system, 173rd Meeting of the Acoustical Society of America, Boston, Massachusetts, 2017

Dezhuang Ye, Cinzia Federico, Vaishali Kapoor, Dinesh Thotala, Dennis E. Hallahan, Kareem Azab, Chen H, Integration of focused ultrasound with nanomedicine for brain drug delivery, 173rd Meeting of the Acoustical Society of America, Boston, Massachusetts, 2017

Kothapalli S., Altman M., Zhu LF, Cheng G. Partanen A., Gach HM, Zoberi I., Hallahan D., and Chen H.. Selection of MR-HIFU hyperthermia treatment sites based on MR thermometry evaluation in healthy volunteers, International Symposium on Therapeutic Ultrasound, Nanjing, China, 2017

Dezhuang Ye, Deborah Sultan, Hannah Luehmann, Yuanchun Tai, Josh Rubin, Yongjian Liu, Chen H, Focused ultrasound-enabled delivery of radiolabeled nanoclusters to the pons with concurrent pet imaging, International Symposium on Therapeutic Ultrasound, Nanjing, China, 2017

Kothapalli S., Altman M., Zhu LF, Cheng G. Partanen A., Gach HM, Zoberi I., Hallahan D., and Chen H. Identification of clinical MR-HIFU hyperthermia treatment sites through validation of MR thermometry accuracy and precision in healthy volunteers, 34th Annual Society for Thermal Medicine Meeting, Cancun, Mexico, 2017

Cammin Jochen, Kothapalli S., Partanen A., Gach HM, Zoberi I., Hallahan D., Chen H. and Altman M., Targetability of Adult Soft Tissue Sarcomas for Mild Hyperthermia Treatments Using Magnetic-Resonance-Imaging guided High-Intensity Focused Ultrasound, 34th Annual Society for Thermal Medicine Meeting, Cancun, Mexico, 2017

Bandara N., Lian S., Ye DZ, Cho HJ, Yue YM, Diebolder P., Mpoy C., Chen H., Mirica LM, Rogers BE. Evaluation of 64Cu-based Radiopharmaceuticals that Target Aβ Peptide Aggregates and Improving BBB Crossing in preclinical models, 22ndInternational Symposium on Radiopharmaceutical Sciences (ISRS 2017), Dresden, Germany, 2017

2016

Satya V.V.N., Leighton, Zhaorui, Ari, H. Michael, William, Michael, Chen, Acoustic Characterization of a Clinical MR-guided HIFU System inside and outside MR Scanner, 5th International Focused Ultrasound Symposium, Bethesda, the USA, 2016.

Lambert E., Ye DZ, Chen H. Janjic JM, Formulation development of PFPE nanoemulsions for HIFU-triggered drug delivery, 252nd American Chemical Society National Meeting, Philadelphia, USA, 2016.

Ye DZ, Raliya R., Biswas P., Chen H. Focused ultrasound-enhanced intranasal brain delivery of gold nanoparticles, IEEE International Ultrasonics Symposium, Tours, France, 2016

 

BEFORE JOINING WUSTL

Chen H, Acosta CJ, Sierra Sanchez CJ, Karakatsani ME, Konofagou EE, Enhanced intranasal brain drug delivery by focused ultrasound-activated microbubbles, IEEE International Ultrasonics Symposium Taipei, Taiwan, 2015

Kamimura HAS, Wang ST, Chen H, Wang Q, Aurup C, Acosta CJ, Carneiro AA, Konofagou EE, Pupil dilation and motor response elicitation by ultrasound neurostimulation, IEEE International Ultrasonics Symposium Taipei, Taiwan, 2015

Kamimura HAS, Carneiro AA, Wang ST, Chen H, Wang Q, Aurup C, Fan KG, Konofagou EE, Noninvasive Ultrasound Neurostimulation, XXXVIII Brazilian Physical Society National Meeting on Condensed Matter Physics, Foz do Igaçu, Brazil, 2015

Kamimura HAS, Wang ST, Chen H, Wang Q, Aurup C, Fan KG, Carneiro AA, Konofagou EE, Ipsi- and contralateral motor response using ultrasound-induced neurostimulation in deeply anesthetized mice, International Congress on Ultrasonics, Metz, France, 2015

Chen H, Acosta CJ, Sierra Sánchez CJ, Karakatsani ME, Konofagou EE, Focused ultrasound-enhanced intranasal drug delivery, 15th International Symposium on Therapeutic Ultrasound, Utrecht, Netherlands, 2015

Chen H, Chen C, Wu SY, Sun T, Konofagou EE, A new brain drug delivery strategy: Focused ultrasound-enhanced intranasal drug delivery, Society for Neuroscience 44th annual meeting, Washington, DC, USA, 2014

Chen H, Payen T, Han Y, Palermo CF, Olive KP, Konofagou EE , Harmonic motion imaging for pancreatic tumor detection and high-intensity focused ultrasound ablation monitoring, 4th International Symposium on Focused Ultrasound, Washington, DC, USA, 2014

Chen H, Han Y, Palermo CF, Olive KP, Konofagou EE, In vivo pancreatic tumor detection and high-intensity focused ultrasound ablation monitoring using harmonic motion imaging technique. IEEE International Ultrasonics Symposium, Chicago, IL, USA, 2014

Chen H, Hou Yi, Han Y, Palermo CF, Olive KP and Konofagou EE, Initial Feasibility of Harmonic Motion Imaging for High-Intensity Focused Ultrasound Ablation of Mouse Pancreatic Tumors, 14th International Symposium on Therapeutic Ultrasound,  Las Vegas, NV, USA, 2014

Chen C, Wu SY, Sun T, Chen H, Konofagou EE, Targeted intranasal drug delivery to the brain using focused ultrasound-induced blood-brain opening,  14th International Symposium on Therapeutic Ultrasound, Las Vegas, NV, USA, 2014

Konofagou EE, Chen C, Chen H, Downs M,  Ferrera V, Olumolade O, Samiotaki G, Sun S, Wang S-T and Wu S-H, Drug delivery through the opened blood-brain barrier in mice and non-human primates, The 165th Meeting of the Acoustical Society of America. Providence, RI, USA, 2014

Chen H, Srivastava A, Sun T, Konofagou EE. Delivery of molecules of various pharmacologically-relevant sizes through blood brain barrier opening induced by long and short ultrasound pulses. The International Society for Therapeutic Ultrasound Symposium. Shanghai, China, 2013

Li T, Chen H, Khokhlova TD, Wang YN, Hwang JH. Passive cavitation monitoring in mouse pancreatic tumors exposured to pulsed high-intensity focused ultrasound. The International Society for Therapeutic Ultrasound Symposium. Shanghai, China, 2013

Perez C, Swalwell J, Tu J, Chen H, Brayman AA, Matula TJ. Acoustic and Optical Characterization of Targeted Ultrasound Contrast Agents. The 165th Meeting of the Acoustical Society of America. Montreal, Quebec, Canada, 2013

Perez C, Brayman AA, Tu J, Swalwell J, Chen H, Matula TJ. Acoustic and optical characterization of ultrasound contrast agents via flow cytometry. The 164th Meeting of the Acoustical Society of America. Kansas City, MO, USA, 2012

Perez C, Chen H, Matula TJ. Characterization of the acoustic field of a clinical electromagnetic shockwave therapy device. The 161th Meeting of the Acoustical Society of America. Seattle, WA, USA, 2011.

Chen H, Perez C, Brayman AA, Matula TJ. High speed imaging of shockwave induced dynamics of cavitation bubbles and vessel wall. The 161th Meeting of the Acoustical Society of America. Seattle, WA, USA, 2011

Chen H, Brayman AA, Matula TJ. Visualizing bubble/vessel interactions. The Artimino Conference on Medical Ultrasound Technology. Artimino, Florence, 2011.

Chen H, Brayman AA, Evan AP, Matula TJ. Mechanisms for microvascular damage induced by ultrasound-activated microbubbles. The International Society for Therapeutic Ultrasound Symposium. New York, NY, USA, 2011.

Hamilton MF, Hay TA, Ilinskii YA, Zabolotskaya EA, Chen H, Kreider W, Bailey MR, Matula TJ. Models for the dynamical interaction of bubbles and blood vessels. The 160th Meeting of the Acoustical Society of America. Cancun, Mexico, 2010.

Chen H, Brayman AA, Evan AP, Matula TJ. Correlating microvessel permeability directly with ultrasound activated microbubble dynamics. The 160th Meeting of the Acoustical Society of America. Cancun, Mexico, 2010.

Chen H, Brayman AA, Wang Y-N, Hwang JH, Evan AP, Kreider W, M.R.Bailey, Matula TJ. Correlation between direct observations of cavitation in blood vessels of ex vivo tissues and associated vascular damage. The International Society for Therapeutic Ultrasound Symposium. Tokyo, Japan, 2010.

Kreider W, Chen H, Bailey MR, Brayman AA, Matula TJ. Bubble-boundary interactions relevant to medical ultrasound. The 159th Meeting of the Acoustical Society of America. Baltimore, MD, USA, 2010.

Chen H, Kreider W, Bailey MR, Brayman AA, Matula TJ. Observations of microbubble translation near vessel walls. The 159th Meeting of the Acoustical Society of America Baltimore, MD, USA, 2010.

Chen H, Brayman AA, Matula TJ. Imaging targeted microbubble interactions with microvessels. IEEE International Ultrasonics Symposium. San Diego, CA, USA, 2010.

Chen H, Brayman AA, Evan AP, Matula TJ. Vascular damage by ultrasound-activated microbubble induced vessel invagination. IEEE International Ultrasonics Symposium, San Diego, CA, USA, 2010.

Chen H, Brayman AA, Matula TJ. The peculiar interactions of microbubbles and microvessels. The 20th International Congress on Acoustics. Sydney, Australia, 2010.

Chen H, Kreider W, Kucewicz JC, Bailey MR, Brayman AA, Matula TJ. Quantitative measurements of microbubble interactions with surrounding vessels and tissues. The 158th Meeting of the Acoustical Society of America. San Antonio, TX, USA, 2009.

Chen H, Brayman AA, Bailey MR, Matula TJ. Direct observation of microbubble interactions with ex vivo microvessels. The 157th Meeting of the Acoustical Society of America. Portland, OR, USA, 2009.

Chen H, Kucewicz J, Kreider W, Brayman AA, Bailey MR, Matula TJ. Observations of bubble-vessel interactions in ultrasound fields. IEEE International Ultrasonics Symposium. Rome, Italy, 2009

Kreider W, Chen H, Bailey MR, Brayman AA, Matula TJ. Potential mechanism for vessel invagination caused by bubble oscillations. IEEE International Ultrasonics Symposium. Rome, Italy, 2009

Chen H, Brayman AA, Matula TJ. Microbubble dynamics in microvessels: Observations of microvessel dilation, invagination and rupture. IEEE International Ultrasonics Symposium. Beijing, China, 2008.

Chen H, Li X, Wan M. High-speed observation of cavitation bubble clouds near a tissue surface in high-intensity focused ultrasound field. World Congress on Ultrasonics-Ultrasonics International. Beijing, China, 2005.

Chen H, Li X, Wan M. The inception of cavitation bubble clouds induced by high-intensity focused ultrasound. World Congress on Ultrasonics-Ultrasonics International. Beijing, China, 2005.