The Blue Ridge Institute for Medical Research (BRIMR) has published rankings of institutions, departments, and investigators based on the funding they receive from the US National Institutes of Health (NIH). We are pleased to announce that Dr. Hong Chen is ranked 11th nationally among all Principal Investigators in Neurosurgery. Additionally, the WashU Neurosurgery ranked No. 5 in NIH […]
Our laboratory is embarking on a new chapter in 2024 by relocating to the Neuroscience Research Building — a 609,000-square-foot, 11-story facility — at 4370 Duncan Ave. The university invested $616 million to construct the building, the largest and most expensive in the medical school’s history. The investment was driven by leaders’ belief that the […]
NIH NIBIB funds the work of more than 5,000 researchers around the country and internationally. Being chosen as an NIH NIBIB Science Highlight is a prestigious recognition. The article “Ultrasound can briefly induce a hibernation-like state in animals” features our innovative research on ultrasound-induced artificial torpor. The piece presents ultrasound as a groundbreaking approach that […]
In just 5 years, our team turned the revolutionary Sonobiopsy technology from concept to commercialization amid the COVID-19 pandemic. This technology provides a noninvasive solution to brain disease diagnostics through the use of focused ultrasound for release of disease-specific biomarkers from brain to blood, which can further be detected and characterized using liquid-based biopsy. Cordance […]
Dr. Hong Chen and Dr. Eric Leuthardt, MD have laid the foundation for a revolutionary technique that noninvasively surveys the molecular and genetic information of brain tumors. This technique, termed sonobiopsy, uses focused ultrasound and microbubbles to precisely and accurately target a brain tumor lesion, temporarily disrupt the blood brain barrier at the target region, […]
The Chen lab recently received two NIH awards to fund their research on ultrasound combined with genetics for treatment of brain disorders. One of the awards — a five-year, $3 million grant from the National Institutes of Health (NIH)’s National Institute of Neurological Disorders and Stroke — will fund the team’s transformative Sonogenetics 2.0 research, […]
Dingyue (Doris) Zhang received her first best poster award at the 15th International Conference on Ultrasound Engineering for Biomedical Applications (IC-UEBA). This award was given to the best three posters during the conference poster sessions. Congratulations to Dingyue on this wonderful achievement!
Some animals have an extraordinary ability to conserve energy by going into torpor, a physiological state marked by reduced body temperature and metabolic activity, which enables them to survive adverse environmental conditions such as harsh weather or lack of food. Hong Chen’s team, led by Yaoheng (Mack) Yang, demonstrated safe and noninvasive induction of torpor-like […]
Among more than 1,500 poster presentations at the 2023 ASGCT annual meeting, Dezhuang (Summer) Ye’s poster won the Outstanding Poster Award. The title of her poster presentation was “Focused ultrasound-mediated intranasal delivery for AAV delivery to targeted brain regions with minimal systemic exposure”.
Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke. Dezhuang (Summer) Ye in collaboration with the team found a noninvasive and nonpharmaceutical method to influence glymphatic […]