Zhongtao Hu

Zhongtao Hu

Zhongtao Hu joined Department of Biomedical Engineering at WUSTL in 2019. He received his Ph.D. in Acoustics at Institute of Acoustics, Chinese Academy of Sciences. He worked on physical acoustics, medical ultrasound, and focused ultrasound related biomedical applications. He is a member of Acoustic Society of America (ASA), Institute of Electrical and Electronics Engineers (IEEE) and International Society for Therapeutic Ultrasound (ISTU). His research interests include developing novel focused ultrasound devices for transcranial ultrasound neuromodulation, precisely drug delivery to brain, and cavitation localization methods for clinical translation.

Academic qualifications:

  • Ph.D., Acoustics, Institute of Acoustics, Chinese Academy of Sciences (Beijing, China), 2019
  • Visiting Scholar, The Leon H. Charney School of Marine Sciences, Haifa University (Israel), 2017
  • B.S., Geophysics, Central South University (Changsha, China), 2014

Awards:

  • Poster award from 2022 GRC In Vivo Ultrasound Imaging, 2022
  • President’s award of Chinese Academy of Sciences, 2019
  • National Scholarship, 2018
  • Student Travel Award from 2016 IEEE International Ultrasonics Symposium, 2016
  • Outstanding Graduates of Central South University, 2014

Publications:

  • Hu, ZT., Yang YH, Lu Xu, Yao Hao and Chen Hong, 2022. Binary acoustic holograms for transcranial focused ultrasound. Frontiers in Neuroscience.
  • Hu, ZT., Yang Y, Xu, L, Jing, Y. and Chen, H., 2022. Airy Beam-enabled Binary Acoustic Metasurfaces for Underwater Ultrasound Beam Manipulation. Physical Review Applied.
  • Hu, ZT., Chen, S., Yang, Y., Gong, Y. and Chen, H., 2022. An affordable and easy-to-use focused ultrasound device for noninvasive and high precision drug delivery to the mouse brain. IEEE Transactions on Biomedical Engineering, 69(9), 2723–2732.
  • Hu, ZT., Xu, L., Chien, C.Y., Yang, Y., Gong, Y., Ye, D., Pacia, C.P. and Chen, H., 2021. 3-D Transcranial Microbubble Cavitation Localization by Four Sensors. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 68(11), pp.3336-3346.
  • Hu, ZT., An, Z., Kong, Y., Lian, G. and Wang, X., 2019. The nonlinear S0 Lamb mode in a plate with a linearly-varying thickness. Ultrasonics, 94, pp.102-108.
  • [Katsnelson, B.G., Hu, ZT.], 2018. Sound Field in a Coastal Wedge in the Area of a Thermocline’s Contact with the Sea Bottom. Bulletin of the Russian Academy of Sciences: Physics, 82(5), pp.526-529. (Co-corresponding author)
  • Hu, ZT., An, ZW., Lian, GX., and Wang, XM., 2017. Propagation properties of backward lamb waves in plate investigated by dynamic photoelastic technique. Chinese Physics Letters, 34(11), p.114301.
  • Hu, ZT., An, ZW., Lian, GX., 2016. Analyses of the interference by residual stresses on ultrasonic images in photoelastic experiment. Journal of Applied Acoustics, (03):206-211.
  • Ye D, Yuan JY, Yang YH, Yue YM, Hu, ZT., Fadera S, Chen H, Focused ultrasound-mediated intranasal delivery for AAV delivery to targeted brain regions with minimal systemic exposure, (Under review, 2022)
  • Xu L, Pacia CP, Gong Y, Hu ZT., Chien CY, Yang LQ, Gach MH, Hao Y, Comron H, Huang JY, Leuthardt, EC, Chen H*, Development of a neuronavigation-guided sonobiopsy device for glioblastoma patients. (Under review, 2022)
  • Ye D, Chen S, Liu YJ, Weixel C, Hu ZT., and Chen H., Mechanically manipulate glymphatic transportation by ultrasound combined with microbubbles. (Under review, 2022)
  • Zuo, W., Hu, ZT., An, Z. and Kong, Y., 2020. LDV-based measurement of 2D dynamic stress fields in transparent solids. Journal of Sound and Vibration, 476, p.115288.
  • An, Z., Hu, ZT., Mao, J., Lian, G. and Wang, XM., 2017, December. Optical visualization of leaky Lamb wave and its application in nondestructive testing. In Proceedings of Meetings on Acoustics 6ICU (Vol. 32, No. 1, p. 030002). Acoustical Society of America.
  • An, Z., Hu, ZT., Lian GX., 2018. Quantitative measurement of ultrasonic stress field in solid media. Journal of Applied Acoustics, (01):1-5.
  • Lian GX., Hu, ZT., Wang, XM., 2018. Observation of hydroelectric shock wave propagating in liquid and solid. Journal of Applied Acoustics, (05):701-705.
  • Xu Z., Zhang SK., Hu, ZT., et al., 2020. Dynamic photoelastic method on the propagation characteristics of asymmetric Lamb mode in thickness variation plate. Journal of Applied Acoustics, (05): 769 – 774.

Conference contributions:

  • Hu, ZT., Yang Y, Xu, L, Jing, Y. and Chen, H., 2022. Airy Beam-enabled Binary Acoustic Metasurfaces (AB-BAMs) for Ultrasound Focusing. Gordon Research Conference (GRC) In Vivo Ultrasound Imaging.
  • Hu, ZT., Chen, S., Yang, Y., Gong, Y., and Chen, H., 2022. Tunable focused ultrasound device for high precise drug delivery to the mouse brain. In 2022 IEEE International Ultrasonics Symposium (IUS).
  • Hu, ZT., Chen, S., Yang, Y., Gong, Y., and Chen, H., 2022. Miniature focused ultrasound device for high precise drug delivery to the mouse brain. Technologies in Brain Cancer Symposium.
  • Hu, ZT., Chen, S., Yang, Y., Gong, Y., & Chen, H., 2022. An affordable and easy-to-use focused ultrasound device for noninvasive and high precision drug delivery to the mouse brain. In International Society for Therapeutic Ultrasound (ISTU)
  • Hu, ZT., Chen, S., Yang, Y., Gong, Y., and Chen, H., 2021. Affordable stereotactic-guided focused ultrasound device for tunable drug delivery to the mouse brain. The Journal of the Acoustical Society of America 150.4 (2021): A129-A129.
  • Hu, ZT., Xu, L., Chien, C.Y., Yang, Y., Gong, Y., Ye, D., Pacia, C.P. and Chen, H., 2021. 3D Transcranial Cavitation Localization Using Four Sensors. In 2021 IEEE International Ultrasonics Symposium (IUS).
  • Hu, ZT., Xu, L., Chien, C.Y., Yang, Y., Gong, Y., Ye, D., Pacia, C.P. and Chen, H., 2020. Transcranial cavitation localization by time difference of arrival algorithm using four sensors. The Journal of the Acoustical Society of America, 148(4), pp.2560-2560.
  • Hu, ZT., Xu L, Yang Y, Gong Y, Ye D, Pacia CP and Chen H, Three-Dimensional Transcranial Cavitation Localization by Four Sensors, (Session title) – Brain technical, 7th International Symposium on Focused Ultrasound, Online, 2020
  • Hu, ZT., Cui, H., An, Z. and Mao, J., 2016, September. Measurements of backward wave propagation using the dynamic photoelastic technique. In 2016 IEEE International Ultrasonics Symposium (IUS) (pp. 1-4). IEEE
  • Hu, ZT., An, Z., Asymmetric propagation of elastic waves in thickness-variable plates, technical Acoustics, National Acoustic Conference, 2018.
  • Hu, ZT., An, Z., et al. The nonlinear S0 Lamb mode in a plate with a linearly-varying thickness. First China Ultrasound Testing Conference, Chongqing, 2018.
  • Hu, ZT., An, Z., et al. Thickness measurement by backward wave motion in plate, the first China ultrasonic nondestructive testing conference, Baotou, 2017.8.
  • Hu, ZT., An, Z., Lian GX. Analysis of the interference of residual stress on ultrasonic image in photoelastic experiment, the 18th national conference on residual stress, Chengdu, 2015.10.

Patents:

  • Separation method of dynamic stress and static stress in dynamic photoelasticity system, CN 105651433 B
  • Stress measurement method based on dynamic light spring system, CN105675186B
  • Ultrasonic stress quantification measuring method for photoelasticity experiment, CN105571752 B
  • High stability dynamic photoelastic ultrasonic quantification measuring device and method, CN108106714A
  • Dynamic photoelastic ultrasonic imaging method and system, CN107884061A
  • Solid plate thickness measuring device based on recession wave and its method, CN 2019103492000A
  • Device for sensing the target at the bottom of solid plate based on leaky lamb wave, CN 2019104513432A