Jinyun Yuan

Jinyun Yuan

Academic qualifications:

  • Ph.D., Biochemistry and Molecular Biology, Tsinghua University (China), 2007
  • M.Sc., Cell Biology, Henan Normal University (China), 2004
  • B.Sc., Biology, Nantong Normal University (China), 2001

Biography:

Jinyun Yuan is currently a senior scientist working in lab. She earned her Ph.D. in Biochemistry and Molecular Biology at Tsinghua University (China) in 2007. She has broad knowledge and experience on hematopoiesis, miRNAs, HIV gene therapy, tuberculosis immunity, cancer immunotherapy and cancer biology. She is focusing on analyzing brain cancer biomarkers release after focus ultrasound and studying the impact of focus ultrasound on brain cancer biology and therapy. 

Publications:

  1. Chukwu C, Yuan JY, Chen H*, Intranasal versus intravenous AAV delivery: A comparative analysis of brain-targeting efficiency and peripheral exposure in mice, Gene Therapy, 202
  2. Yuan J, Chen H, Sonobiopsy for sensitive and spatially targeted molecular diagnosis through integrating ultrasound with liquid biopsy, npj acoustics, 2025
  3. Yang YH, Yuan Y, Field RL, Ye DZ, Hu ZT, Xu K, Gong Y, Yue YM, Kravitz A, Bruchas MR, Cui JM, Brestoff JR, and Chen H, Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound, Nature Metabolism, 2023; 5, 789–803.
  4. Yuan JY*, Xu L*, Chien CY*, Yang YH, Yue YM, Fadera S, Stark AH, Schwetye KE, Nazeri A, Desai R, Athiraman U, Chaudhuri AA, Chen H*, Leuthardt E*, First-in-human prospective trial of sonobiopsy in glioblastoma patients using neuronavigation-guided focused ultrasound, NPJ Precision Oncology, 2023; 7: 92.
  5. Ye D, Yuan JY, Yang YH, Yue YM, Hu ZT, Fadera S, Chen H, Incisionless targeted adeno-associated viral vector delivery to the brain by focused ultrasound-mediated intranasal administration, eBioMedicine, 2022; 84:104277.
  6. Pacia CP*, Yuan JY*, Yue Y, Xu L, Nazeri A, Desai R, Gach HM, Wang XW, Talcott MR, Chaudhuri AA, Dunn GP, Leuthardt EC, Chen H, Sonobiopsy for noninvasive, spatiotemporally-controlled, and sensitive detection of glioblastoma-derived circulating tumor DNA, Theranostics. 2022; 12(1):362-378.
  7. Yuan J, Ye D, Chen S, Chen H, Therapeutic ultrasound-enhanced immune checkpoint inhibitor therapy. Frontiers in Physics, 2021; 8:102
  8. Yuan J, Tenant J, Pacatte J, Eickhoff C, Blazevic A, Hoft, DF, Chatterjee S. A subset of Mycobacteria-specific CD4+ IFN-γ+ T cells expressing naïve phenotype confers protection against tuberculosis infection in the lung. J Immunol. 2019 Aug 15;203(4):972-980
  9. Berrien-Elliott MM, Yuan JY, Swier LE, Jackson SR, Chen CL, Donlin MJ, Teague RM. Checkpoint blockade immunotherapy relies on T-bet but not Eomes to induce effector function in tumor-infiltrating CD8+ T cells. Cancer Immunol Res. 2015 Feb;3(2):116-24.
  10. Jackson SR, Yuan JY, Teague RM. Targeting CD8+ T-cell tolerance for cancer immunotherapy. Immunotherapy. 2014;6(7):833-52.
  11. Jackson SR, Yuan JY, Berrien-Elliott MM, Chen CL, Meyer JM, Donlin MJ, Teague RM. Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional tolerance. J Leukoc Biol. 2014 Sep;96(3):397-410.
  12. Yuan J, Wang J, Crain K, Fearns C, Kim KA, Hua KL, Gregory PD, Holmes MC, Torbett BE. Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4(+) T Cell Resistance and Enrichment. Mol Ther. 2012 Apr;20(4):849-59.
  13. Yuan J, Devarajan A, Moya-Castro R, Zhang M, Evans S, Bourquard N, Dias P, Lacout C, Vainchenker W, Reddy ST, Koka PS. Putative innate immunity of antiatherogenic paraoxanase-2 via STAT5 signal transduction in HIV-1 infection of hematopoietic TF-1 cells and in SCID-hu mice. J Stem Cells. 2010; 5(1):43-8.
  14. Yuan J*, Wang F*, Yu J*, Yang GH, Liu XL, Zhang JW. MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4551-9. (*Co-first authors)
  15. Liu XL*, Yuan JY*, Zhang JW, Zhang XH, Wang RX. Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryocytic, and granulocytic lineage. J Leukoc Biol. 2007 Oct; 82(4):986-1002. (*Co-first authors)

*The authors contributed equally to this work.