Noninvasive Sonobiopsy is Feasible and Safe in Humans

Dr. Hong Chen and Dr. Eric Leuthardt, MD have laid the foundation for a revolutionary technique that noninvasively surveys the molecular and genetic information of brain tumors. This technique, termed sonobiopsy, uses focused ultrasound and microbubbles to precisely and accurately target a brain tumor lesion, temporarily disrupt the blood brain barrier at the target region, […]

Chen Lab received two NIH R01 awards 

The Chen lab recently received two NIH awards to fund their research on ultrasound combined with genetics for treatment of brain disorders. One of the awards — a five-year, $3 million grant from the National Institutes of Health (NIH)’s National Institute of Neurological Disorders and Stroke — will fund the team’s transformative Sonogenetics 2.0 research, […]

Dingyue received best poster award at 2023 IC-UEBA

Dingyue (Doris) Zhang received her first best poster award at the 15th International Conference on Ultrasound Engineering for Biomedical Applications (IC-UEBA). This award was given to the best three posters during the conference poster sessions. Congratulations to Dingyue on this wonderful achievement!

Hong Chen’s Team Induces Torpor-Like State Using Ultrasound

Some animals have an extraordinary ability to conserve energy by going into torpor, a physiological state marked by reduced body temperature and metabolic activity, which enables them to survive adverse environmental conditions such as harsh weather or lack of food. Hong Chen’s team, led by Yaoheng (Mack) Yang, demonstrated safe and noninvasive induction of torpor-like […]

Our glymphatic paper is published in PNAS

Like the lymphatic system in the body, the glymphatic system in the brain clears metabolic waste and distributes nutrients and other important compounds. Impairments in this system may contribute to brain diseases, such as neurodegenerative diseases and stroke. Dezhuang (Summer) Ye in collaboration with the team found a noninvasive and nonpharmaceutical method to influence glymphatic […]

Yaoheng Yang Wins BME PhD Thesis Award

Congratulations to Dr. Yaohang (Mack) Yang for winning the BME PhD Outstanding Dissertation Award at WashU! This award is given to recognize a comprehensive body of independent scholarship that significantly advances the discipline. Yaohang’s thesis work has undoubtedly advanced the field of sonogenetics and neuromodulation. Congratulations for your amazing achievements!

We are hiring!

POSITION SUMMARY We are actively looking for highly motivated PhD students, postdocs, and staff scientists to join our dynamic and collaborative lab situated at Washington University Medical School. Our lab is generously funded by the NIH and is dedicated to developing innovative tools for modulating neuron activities, diagnosing brain diseases, and revolutionizing their treatment. Our […]

Focused ultrasound-mediated liquid biopsy detects biomarkers of neurodegenerative disorders

The Hong Chen lab is developing a noninvasive method for release and detection of biomarkers characteristic of neurodegenerative disorders. Tau proteins in the brain are characteristic of several neurodegenerative disorders, and the Chen Ultrasound lab, along with collaborators, have found that using focused-ultrasound-mediated liquid biopsy, a method known as sonobiopsy, in a mouse model released […]

Chen Ultrasound Lab receives R01 from NCI in collaboration with Dr. Eric Leuthardt

A total of $3.2 million fund is awarded to Drs. Leuthardt and Chen for five years in support of their clinical study of an ultrasound-mediated blood-based liquid biopsy technique for noninvasive molecular diagnosis of glioblastoma. Glioblastoma patients will be recruited to evaluate the feasibility and safety of this technique. Developing a noninvasive technique to diagnose […]

Dezhuang Receives Young Investigator Award & Bracco Women in Science Award

Dezhuang (Summer) Ye recently received the Young Investigator Award at the 8th International Symposium on Focused Ultrasound. This award recognizes outstanding research by scientists-in-training in the field of focused ultrasound. Dezhuang was awarded for her work on ultrasound enabled incisionless brain gene delivery and ultrasound manipulation of the glymphatic system. At the symposium, Dezhuang also […]

Chinwendu Chukwu Receives Poster Award at WashU’s BME PhD Retreat

Chinwendu (Chinwe) Chukwu received an “Early Stage” PhD Student award at WashU’s 2022 BME PhD retreat. This award was given to early-stage doctoral candidates who presented promising research during the retreat’s poster sessions. Congratulations to Chinwe on this wonderful achievement!

Chen Lab Develops Noninvasive FUS-Mediated Intranasal Delivery Method

Led by Dr. Dezhuang (Summer) Ye, the Chen lab recently developed a new method for delivering genes to the brain, called Focused Ultrasound-mediated Intranasal Delivery (FUSIN). Dr. Ye and her team recently found that the FUSIN-delivered genes had comparable or better outcomes than existing methods while minimizing systemic effects on other organs. Dr. Ye’s study […]

Yaoheng Yang Receives SfN’s 2022 Trainee Professional Development Award

Yaoheng (Mack) Yang has been selected as a recipient of a 2022 Trainee Professional Development Award (TPDA) from the Society of Neuroscience (SfN). This award is given to scientists who have demonstrated great merit and strength in their research. Congratulations, Mack, on this wonderful achievement!

Chen Lab Develops New Practical Method for Generating Airy Beams

Led by Zhongtao Hu, the Chen lab recently developed a unique technique for generating ultrasound waves that can self-bend. The team designed and 3D printed a flexible and versatile tool known as Airy beam-enabled binary acoustic metasurfaces (AB-BAMs) for ultrasound beam manipulation. They then demonstrated the capability of AB-BAMs in water, as depicted in the […]

Chen Lab Retreat 2022

The Chen Ultrasound Lab had an eventful past weekend as they journeyed to Ridgedale, MO for their annual lab retreat. During the retreat, lab members participated in team building activities such as hiking through Table Rock Lakeshore Trail, relaxing at Moonshine Beach, and participating in a science-themed trivia game night. The team has plenty of […]

Zhongtao Received Poster Award at The 2022 Gordon Conference

Zhongtao Hu received a Poster Award at the 2022 Gordon Conference on In Vivo Ultrasound Imaging. He presented on his design and 3D printing of the Airy Beam-enabled Binary Acoustic Metasurfaces (AB-BAMs). This tool enables flexible and versatile ultrasound beam manipulation, including a sharply focused, tunable, steerable beam, which is useful for various ultrasound applications. […]

WUSEF Students Join Chen Lab For Summer 2022

Two students, Natalia Alonzo (left) and Camila Maneiro (right), have joined the Chen lab for summer 2022. These undergraduate students are part of WashU’s Summer Engineering Fellowship (WUSEF) program, a program designed to encourage exceptional STEM students from underrepresented backgrounds to participate in engineering research. We are very excited to have Natalia and Camila this summer […]

Hong Chen Receives $750K To Develop Wearable Sensors

Dr. Hong Chen has received a three-year, $750,000 grant from the Office of Naval Research to fund research on the development of wearable ultrasound sensors for the detection of cavitation in human brain. To read more about this, please visit here. Congratulations to the Chen lab team on the new grant!

Congratulations Dr. Chris Pacia!

Dr. Chris Pacia defended his thesis in April and has successfully earned his PhD from WashU! Chris has been an invaluable member of the lab since he joined and he is very proud of the work he accomplished these past few years. Chris will begin his next chapter as an Associate Consultant at Triangle Insights […]